Tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane → 2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane	HCID 4555750	—
Reactant	4-(2-(5-Amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenol	HCID 58166509	—
Product	2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine	HCID 66875193	—

Reaction Steps

2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine was prepared following an analogous procedure to the preparation described for Example 145/Step 1, but using 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenol (from Example 50) with tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08895577B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-f2eb2d3eb06d43358278a710dd3e9ca7
Source note	uspto-grants-2014_11