1,4-Dioxane hydrochloride → HCID 86762499, compound

HRID 340447Notes

Reaction equation

HRID 340447 reaction equation
[ClH:1].O1CCOCC1.C(OC(=O)[NH:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(C)(C)C>C(OCC)(=O)C>[CH3:26][N:22]1[CH:23]=[CH:24][CH:25]=[C:21]1[C:19]1[CH:20]=[C:15]([NH2:14])[CH:16]=[N:17][CH:18]=1.[ClH:1]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 89546762HCID 89546762, compound

Product 1

HCID 86762499HCID 86762499, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4M hydrogen chloride/1,4-dioxane (1 ml) was added to an ethyl acetate (2 ml) solution containing tert-butyl(5-(1-methyl-1H-pyrrol-2-yl)pyridin-3-yl)carbamate (80 mg) obtained in the 1st step, followed by stirring at room temperature for 15 hours. An insoluble precipitate was collected by filtration, and a light brown solid of 5-(1-methyl-1H-pyrrol-2-yl)pyridin-3-amine•hydrochloride (42 mg) was thus obtained.

Workup

  1. customobtained in the 1st step
  2. filtrationAn insoluble precipitate was collected by filtration

Sources & evidence

ORD record
ord-0a5a678b85fa4bfeb41d5e1d92ddaa1c
Source dataset
uspto-grants-2014_11
Patent number
US08895585B2

Reaction notes

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