反应详情

TFA (1 ml) was added to a chloroform (1 ml) solution containing tert-butyl(5-(1H-pyrrol-1-yl)pyridin-3-yl)carbamate (36 mg) obtained in the 1st step, followed by stirring at room temperature for 1 hour. Then, the solvent was distilled away under reduced pressure and the residue was added to a mixture of chloroform, water, and a 1M sodium hydroxide aqueous solution, followed by extraction with chloroform. The resultant was dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a light brown solid of 5-(1H-pyrrol-1-yl)pyridin-3-amine (23 mg) was thus obtained.

1. customobtained in the 1st step
2. distillationThen, the solvent was distilled away under reduced pressure
3. additionthe residue was added to a mixture of chloroform, water
4. extractiona 1M sodium hydroxide aqueous solution, followed by extraction with chloroform
5. dry with materialThe resultant was dried over anhydrous sodium sulfate
6. distillationthe solvent was distilled away under reduced pressure