Hydrazine hydrate (1:1) → 6-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic Acid Hydrazide

HRID 34055Notes

Reaction equation

HRID 34055 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)=[N:7][N:8]2[C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][C:3]=1[C:38](O)=[O:39].O.[NH2:42][NH2:43]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)=[N:7][N:8]2[C:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[CH:4][C:3]=1[C:38]([NH:42][NH2:43])=[O:39]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68928596HCID 68928596, compound

Product 1

HCID 689355106-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic Acid HydrazideYield 25.7%

Procedure

In accordance with the method as described in Example 127, 110 mg of 6-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic acid and 210 mg of hydrazine monohydrate were condensed, to afford 29 mg of the title compound as a yellow powder.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-c81e364c5b154766885a9b22cd07c686
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

Loading…