Sodium Hydroxide → 2-Hydroxy-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]propanamide

HRID 340734Notes

Reaction equation

HRID 340734 reaction equation
C([O:4][CH:5]([CH3:24])[C:6]([NH:8][CH2:9][CH2:10][CH:11]1[C:22]2[C:21]3[O:20][C:19]([CH3:23])=[N:18][C:17]=3[CH:16]=[CH:15][C:14]=2[CH2:13][CH2:12]1)=[O:7])(=O)C.[OH-].[Na+]>O1CCCC1>[OH:4][CH:5]([CH3:24])[C:6]([NH:8][CH2:9][CH2:10][CH:11]1[C:22]2[C:21]3[O:20][C:19]([CH3:23])=[N:18][C:17]=3[CH:16]=[CH:15][C:14]=2[CH2:13][CH2:12]1)=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 577812671-Methyl-2-{[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]amino}-2-oxoethyl Acetate

Product 1

HCID 577812182-Hydroxy-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]propanamideYield 86%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-methyl-2-{[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]amino}-2-oxoethyl acetate (70 mg, 0.212 mmol) in tetrahydrofuran (2 mL) was added 1N aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure. The residue was diluted with ethyl acetate, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (52.4 mg, yield 86%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionThe residue was diluted with ethyl acetate
  3. washwashed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure
  6. customthe residue was purified by silica gel column chromatography (methanol/ethyl acetate)

Sources & evidence

ORD record
ord-f6b8981b2d344b48ba93cd40887b6307
Source dataset
uspto-grants-2014_11
Patent number
US08895591B2

Reaction notes

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