反应详情

1.36 g of 2-chloro-4-methylpyrimidin-5-ylamine was dissolved in 20 mL of dichloromethane, and under stirring on ice, 1.53 mL of pyridine, 2.7 mL of acetic anhydride and 1.16 g of 4-dimethylaminopyridine were added. After stirring at room temperature for 1 hour, water was added, extracted with ethyl acetate, and the resultant organic layer was washed with saturated brine and dried over magnesium sulfate. After evaporating the solvent, the residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1), to afford 178 mg of the title compound as a brown oil.

1. additionwere added
2. extractionextracted with ethyl acetate
3. washthe resultant organic layer was washed with saturated brine
4. dry with materialdried over magnesium sulfate
5. customAfter evaporating the solvent
6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1)