Hydrochloric Acid → HCID 57947846, compound

HRID 340890Notes

Reaction equation

HRID 340890 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([C:13]([NH:15][NH2:16])=[O:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[N:18]([O-])=O.[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([C:13]([N:15]=[N+:16]=[N-:18])=[O:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 57947817HCID 57947817, compound

Product 1

HCID 57947846HCID 57947846, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a suspension of 5-(3-fluorophenyl)isoxazole-3-carbohydrazide (22.5 g, 101 mmol) in H2O (2000 mL) and HCl (2 N, 101 mL, 2.0 equiv.) at 0° C. was added a solution of sodium nitrite (13.9 g, 202 mmol, 2.0 equiv.) in H2O (100 mL). The suspension was stirred at RT for 16 h. The precipitate was filtered and washed with H2O. The solid was dried under high vacuum to give 5-(3-fluorophenyl)isoxazole-3-carbonyl azide as a yellow solid (20 g, 85%). LRMS (M+H+) m/z 179.0.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with H2O
  3. customThe solid was dried under high vacuum

Sources & evidence

ORD record
ord-ae322284f39947da9e225aa5caf1ff9a
Source dataset
uspto-grants-2014_11
Patent number
US08895582B2

Reaction notes

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