反应详情

To a solution of 4-(4-Bromo-phenoxy)-piperidine (1 g, 3.9 mmol) in dioxane (20 ml), water (20 ml) added Na2CO3 (1.6 g, 18.9 mmol) and (BOC)2O (1.3 g, 5.9 mmol). Reaction stirred at ambient for 48 hours, solvent was removed under reduced pressure and residue partitioned between EtOAc and water the layers were separated. The organic layer was washed with brine, dried (MgSO4), and concentrated under reduced pressure to give (1.2 g) of product.

1. customReaction
2. customsolvent was removed under reduced pressure and residue
3. custompartitioned between EtOAc and water the layers
4. customwere separated
5. washThe organic layer was washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated under reduced pressure