HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-3-(morpholin-4-yl)propan-2-ol → 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-3-(morpholin-4-yl)propan-2-ol | HCID 2832231 | — |
| Reactant | 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid | HCID 59797243 | — |
| Product | 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide | HCID 60034861 | 45.4% |
Reaction Steps
100 mg of 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid obtained by Example 234 and 130 mg of 1-amino-3-(morpholine-4-yl)propane-2-ol were condensed in the similar method as described in Example 44, to afford 66 mg of the title compound as colorless needle crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429609B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-cdbb4289407b462dab29ea96153df71a |
| Source note | uspto-grants-2008_09 |