HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 44176786, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 59320870 | HCID 59320870 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 44176786 | HCID 44176786 | 15.1% |
Reaction Steps
Trifluoroacetic acid (1 ml) was added to a stirred solution of [2-(3-{3-[7-(4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-ureido)-ethyl]-carbamic acid tert-butyl ester (85 mg, 0.17 mmol) in CH2Cl2 (2 ml) at 0° C. After 1 h the volatiles were removed in vacuo and the residue was purified by preparative HPLC to give the title compound (10 mg, solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895745B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-af1d2184507645128186506e2d11b43e |
| Source note | uspto-grants-2014_11 |