Trifluoroacetic acid → HCID 44176786, compound

HRID 341178Notes

Reaction equation

HRID 341178 reaction equation
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][CH2:15][CH2:16][NH:17][C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2[N:31]3[CH:32]=[CH:33][C:34]([C:36]4[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=4)=[CH:35][C:30]3=[N:29][CH:28]=2)[CH:22]=1)=[O:19])(C)(C)C>C(Cl)Cl>[NH2:14][CH2:15][CH2:16][NH:17][C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2[N:31]3[CH:32]=[CH:33][C:34]([C:36]4[CH:37]=[CH:38][C:39]([F:42])=[CH:40][CH:41]=4)=[CH:35][C:30]3=[N:29][CH:28]=2)[CH:22]=1)=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59320870HCID 59320870, compound

Product 1

HCID 44176786HCID 44176786, compoundYield 15.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (1 ml) was added to a stirred solution of [2-(3-{3-[7-(4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-ureido)-ethyl]-carbamic acid tert-butyl ester (85 mg, 0.17 mmol) in CH2Cl2 (2 ml) at 0° C. After 1 h the volatiles were removed in vacuo and the residue was purified by preparative HPLC to give the title compound (10 mg, solid).

Workup

  1. customAfter 1 h the volatiles were removed in vacuo
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-af1d2184507645128186506e2d11b43e
Source dataset
uspto-grants-2014_11
Patent number
US08895745B2

Reaction notes

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