反应详情

To a solution of Imidazo[1,2-a]pyridine-7-carboxylic acid methoxy-methyl-amide (187 mg, 0.91 mmol) in THF (10 ml) at −78° C. was added 1-propynylmagnesium bromide (0.5M in THF, 2.74 ml). The reaction was allowed to warm to room temperature and stirred for 1.5 h before being quenched with 2M HCl (2 ml) and washed with CH2Cl2. The aqueous fraction was basified using Na2CO3 and extracted with CH2Cl2. The organic fraction was dried (MgSO4), filtered and the solvent removed in vacuo to afford the product (168 mg). MS: [M+H]+=185.

1. custombefore being quenched with 2M HCl (2 ml)
2. washwashed with CH2Cl2
3. extractionextracted with CH2Cl2
4. dry with materialThe organic fraction was dried (MgSO4)
5. filtrationfiltered
6. customthe solvent removed in vacuo