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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34121Generated: October 30, 2026

Trifluoroacetic acid → HCID 60034647, compound

https://huagongshe.com/reaction/34121

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-butyl 4-[2-[[3-[(E)-2-(4-fluorophenyl)ethenyl]-4-methoxy-1H-indazole-5-carbonyl]amino]acetyl]piperazine-1-carboxylateHCID 60034979—
SolventDichloromethaneHCID 6344—
ProductHCID 60034647HCID 60034647—

Reaction Steps

4-[2-({3-[(E)-2-(4-Fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester obtained by Example 1215 was dissolved in 1 mL of dichloromethane, added with 1 mL of trifluoroacetic acid, and stirred at room temperature for 2 hours. The solvent was evaporated, followed by purification by LC-MS, to afford the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429609B2
Source datasetuspto-grants-2008_09
ORD IDord-b26fb631a22b4337a34d848d6b359e77
Source noteuspto-grants-2008_09