Trifluoroacetic acid → HCID 60034647, compound

HRID 34121Notes

Reaction equation

HRID 34121 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:39])[CH2:15][NH:16][C:17]([C:19]2[C:20]([O:37][CH3:38])=[C:21]3[C:25](=[CH:26][CH:27]=2)[NH:24][N:23]=[C:22]3/[CH:28]=[CH:29]/[C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)=[O:18])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[O:39]=[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH2:15][NH:16][C:17]([C:19]1[C:20]([O:37][CH3:38])=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][N:23]=[C:22]2/[CH:28]=[CH:29]/[C:30]1[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=1)=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 60034979tert-butyl 4-[2-[[3-[(E)-2-(4-fluorophenyl)ethenyl]-4-methoxy-1H-indazole-5-carbonyl]amino]acetyl]piperazine-1-carboxylate

Product 1

HCID 60034647HCID 60034647, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[2-({3-[(E)-2-(4-Fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester obtained by Example 1215 was dissolved in 1 mL of dichloromethane, added with 1 mL of trifluoroacetic acid, and stirred at room temperature for 2 hours. The solvent was evaporated, followed by purification by LC-MS, to afford the title compound.

Workup

  1. customThe solvent was evaporated
  2. customfollowed by purification by LC-MS

Sources & evidence

ORD record
ord-b26fb631a22b4337a34d848d6b359e77
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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