Hydrochloric Acid → 1-((Dimethylamino)methyl)cyclopropanecarboxylic acid

HRID 34124Notes

Reaction equation

HRID 34124 reaction equation
C([O:3][C:4]([C:6]1([CH2:9][N:10]([CH3:12])[CH3:11])[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[CH3:11][N:10]([CH2:9][C:6]1([C:4]([OH:5])=[O:3])[CH2:8][CH2:7]1)[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 60034732Ethyl 1-[(dimethylamino)methyl]cyclopropanecarboxylate

Product 1

HCID 230701411-((Dimethylamino)methyl)cyclopropanecarboxylic acidYield 42%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 222 mg of 1-dimethylaminomethyl-cyclopropane carboxylic acid ethyl ester in 0.4 mL of ethanol was added 0.1 mL of 5N sodium hydroxide aqueous solution, and stirred overnight at room temperature. The reaction solution was added with 0.5 mL of 1N hydrochloric acid, and the solvent and water were evaporated, to give 78 mg of a mixture of the title compound and sodium chloride as a white powder.

Workup

  1. customthe solvent and water were evaporated

Sources & evidence

ORD record
ord-0c5b3d9ae7dd417b88006538662a5308
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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