反应详情

To a suspension of Methyl-3-Iodo-imidazo[1,2-a]pyridine-7-carboxylate (0.4 g, 1.32 mmol) in MeOH (6 ml) was added hydrazine hydrate (0.25 ml, 5.28 mmol). The mixture was refluxed for 4 h then further hydrazine hydrate (0.25 ml, 5.28 mmol) was added, the mixture heated o/n, allowed to cool, solid was filtered off and washed with MeOH and dried to afford 0.36 g of product. MS: [M+H]+ 303.

1. temperatureThe mixture was refluxed for 4 h
2. temperaturethe mixture heated o/n,
3. temperatureto cool
4. filtrationsolid was filtered off
5. washwashed with MeOH
6. customdried