Methyl isothiocyanate → HCID 59320877, compound

HRID 341245Notes

Reaction equation

HRID 341245 reaction equation
[NH:1]([C:3]([C:5]1[CH:10]=[CH:9][N:8]2[C:11]([C:14]3[CH:15]=[C:16]([NH:20][C:21]([NH:23][CH2:24][C:25]([F:28])([F:27])[F:26])=[O:22])[CH:17]=[CH:18][CH:19]=3)=[CH:12][N:13]=[C:7]2[CH:6]=1)=O)[NH2:2].[CH3:29][N:30]=[C:31]=[S:32]>CCO>[CH3:29][N:30]1[C:31](=[S:32])[NH:2][N:1]=[C:3]1[C:5]1[CH:10]=[CH:9][N:8]2[C:11]([C:14]3[CH:15]=[C:16]([NH:20][C:21]([NH:23][CH2:24][C:25]([F:28])([F:27])[F:26])=[O:22])[CH:17]=[CH:18][CH:19]=3)=[CH:12][N:13]=[C:7]2[CH:6]=1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 59320927HCID 59320927, compound

Product 1

HCID 59320877HCID 59320877, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-[3-(7-hydrazinocarbonyl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea (90 mg, 0.23 mmol) and methyl isothiocyanate (17 mg, 0.23 mmol) were heated in EtOH (3 ml) at 70° C. for 18 h. The reaction mixture was allowed to cool and the precipitate formed filtered off to give the product (34 mg). MS: [M+H]+ 447

Workup

  1. temperatureto cool
  2. customthe precipitate formed
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-6325bc5475154e36a4277f6daadb5573
Source dataset
uspto-grants-2014_11
Patent number
US08895745B2

Reaction notes

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