Acetic Anhydride → N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

HRID 34126Notes

Reaction equation

HRID 34126 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH2:16])=[C:11]([CH3:17])[CH:10]=1>>[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH:16][C:5](=[O:7])[CH3:6])=[C:11]([CH3:17])[CH:10]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 70180444-Bromo-5-fluoro-2-methylaniline

Product 1

HCID 23070217N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

Procedure

73.6 mL of acetic anhydride was added with 80.0 g of 4-bromo-5-fluoro-2-methylphenylamine at room temperature, and stirred at this temperature for 10 minutes. Excess acetic anhydride was distilled off under reduced pressure, and the precipitated crystals were washed with water, to afford 77.6 g of the title compound as colorless crystal.

Workup

  1. distillationExcess acetic anhydride was distilled off under reduced pressure
  2. washthe precipitated crystals were washed with water

Sources & evidence

ORD record
ord-d239774155d24cce85ad6d774c49788d
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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