反应详情

A mixture of 3.4 g of 2-amino-7-chloro-6-(4-methoxyphenyl)-pyrido[2,3-d]pyrimidine from Example 12, 40 mL of anhydrous methylamine, and 10 mL of methanol were heated in a bomb on a steam bath for 4 hours. After cooling, the suspension was washed out of the bomb with 50 mL of methanol/water (50:50) and the solvents were evaporated in vacuo. The solid residue was slurried with 50 mL of water, filtered, and crystallized from ethanol to afford 2.2 g of the title compound 6-(4-methoxyphenyl)-N7 -methyl-pyrido[2,3-d]pyrimidine-2,7-diamine, mp 270°-275° C. dec.

1. temperaturewere heated in a bomb on a steam bath for 4 hours
2. temperatureAfter cooling
3. washthe suspension was washed out of the bomb with 50 mL of methanol/water (50:50)
4. customthe solvents were evaporated in vacuo
5. filtrationfiltered
6. customcrystallized from ethanol