Trifluoroacetic acid → HCID 178525982, compound

HRID 34141Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@@H:20]([C:31]1[NH:35][C:34]2[CH:36]=[CH:37][C:38]([Cl:40])=[CH:39][C:33]=2[N:32]=1)[CH2:21][O:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@@H:20]([C:31]1[NH:35][C:34]2[CH:36]=[CH:37][C:38]([Cl:40])=[CH:39][C:33]=2[N:32]=1)[CH2:21][O:22][CH2:23][C:24]([OH:26])=[O:25]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178451360HCID 178451360, compound

Product 1

HCID 178525982HCID 178525982, compound

Procedure

Prepared analogously to Example 8c from 6-chloro-4-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(tert.-butyloxycarbonylmethoxy)-ethylamino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and trifluoroacetic acid.

Sources & evidence

ORD record: ord-3d729488e2344c25988d211edd16977b
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429597B2

Reaction notes

Loading…