Sodium Hydroxide → Sodium 3-methoxypyridine-2-carboxylate

HRID 341483Notes

Reaction equation

HRID 341483 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:9]([O:11]C)=[O:10])=[N:5][CH:6]=[CH:7][CH:8]=1.[OH-].[Na+:14]>CO>[CH3:1][O:2][C:3]1[C:4]([C:9]([O-:11])=[O:10])=[N:5][CH:6]=[CH:7][CH:8]=1.[Na+:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20474189Methyl 3-methoxypyridine-2-carboxylate2×

Product 1

HCID 66803094Sodium 3-methoxypyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of methyl 3-methoxypyridine-2-carboxylate (Intermediate 95, 0.55 g, 3.3 mmol) in methanol (10 ml) was added dropwise aqueous sodium hydroxide solution (1M, 4 ml, 4 mmol). The mixture was left to stand overnight. The mixture was concentrated under vacuum to give a white solid, which was used without further purification or characterisation.

Workup

  1. waitThe mixture was left
  2. concentrationThe mixture was concentrated under vacuum
  3. customto give a white solid, which
  4. customwas used without further purification or characterisation

Sources & evidence

ORD record
ord-bb216226dc1f43a8afb8db2a6f90938b
Source dataset
uspto-grants-2014_11
Patent number
US08895733B2

Reaction notes

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