Hydrazine hydrate (1:1) → HCID 66628949, compound

HRID 341634Notes

Reaction equation

HRID 341634 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2C(=O)C3C(=CC=CC=3)C2=O)[CH:11]=[CH:12][CH:13]=1.O.NN>>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66628904HCID 66628904, compound

Product 1

HCID 66628949HCID 66628949, compound

Procedure

Deprotection of 2-(4-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)butyl)isoindoline-1,3-dione with hydrazine monohydrate following the method used in Example 17 except that the reaction mixture was heated at +50° C. for 16 hrs afforded 4-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)butan-1-amine as a colorless oil, which was used in the next step without purification.

Workup

  1. temperaturewas heated at +50° C. for 16 hrs

Sources & evidence

ORD record
ord-4fb9bb6bbf9443b1b0ca26cfe1d2941c
Source dataset
uspto-grants-2014_11
Patent number
US08895782B2

Reaction notes

Loading…