huagongshe.com
HRID341636

反应详情

EQUATION

反应方程式

HRID 341636 的结构方程式

REACTANTS

反应物

4
结构：O=P([O-])([O-])[O-].[K+].[K+].[K+]
HCID62657

Tripotassium phosphate

K3O4P

结构：OB(O)c1ccc2cc(O)ccc2c1
HCID4349738

(6-Hydroxynaphthalen-2-yl)boronic acid

C10H9BO3

2 次

结构：CC12CC3(C)OC(C)(CC(C)(O1)P3c1ccccc1)O2
HCID53427790

1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.1~3,7~]decane

C16H21O3P

结构：COc1c(I)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C
HCID57493877

1-(3-tert-Butyl-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

C15H17IN2O3

2 次

PRODUCTS

生成物

1
结构：COc1c(-c2ccc3cc(O)ccc3c2)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C
HCID56640670

1-[3-(6-Hydroxy-2-naphthyl)-4-methoxy-5-(2-methyl-2-propanyl)phenyl]-2,4(1H,3H)-pyrimidinedione

C25H24N2O4

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

In an embodiment, 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione (compound (1c) is reacted with 6-hydroxynaphthalen-2-ylboronic acid (compound (3a) in tetrahydrofuran in the presence of potassium phosphate tribasic, 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane, and tris(dibenzylideneacetone)dipalladium(0) to provide 1-(3-tert-butyl-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione (compound (4)).