反应详情

温度

80 °C

A mixture of mercury (II) acetate (2.7 g, 0.0084 mol), sulfuric acid (2.7 ml, 0.027 mol), water (270 ml) and 3,6-dimethyl-oct-4-yne-3,6-diol (27.0 g, 0.159 mol) is heated at 80° C. The reaction mixture is maintained at 80° C. for 4 hours and allowed to cool to ambient temperature. The mixture is extracted with diethyl ether (3×150 ml), the organic phases are combined, washed with water, and dried over anhydrous sodium sulfate. The mixture is filtered and the filtrate is evaporated under reduced pressure to give 2,5-diethyl-2,5-di-methyldihydrofuran-3-one (20 g) as a colourless oil.

1. temperatureThe reaction mixture is maintained at 80° C. for 4 hours
2. temperatureto cool to ambient temperature
3. extractionThe mixture is extracted with diethyl ether (3×150 ml)
4. washwashed with water
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationThe mixture is filtered
7. customthe filtrate is evaporated under reduced pressure