Trifluoroacetic acid → HCID 178525451, compound

HRID 34175Notes

Reaction equation

HRID 34175 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH:17]=[CH:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:31]1[NH:35][C:34]2[CH:36]=[CH:37][C:38]([Cl:40])=[CH:39][C:33]=2[N:32]=1)[CH2:21][CH2:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:15][CH:16]=[CH:17][CH2:18]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:31]1[NH:35][C:34]2[CH:36]=[CH:37][C:38]([Cl:40])=[CH:39][C:33]=2[N:32]=1)[CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450997HCID 178450997, compound

Product 1

HCID 178525451HCID 178525451, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 8c from 6-chloro-4-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-4-(tert.-butyloxycarbonyl)-butylamino]-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline and trifluoroacetic acid in dichloromethane.

Sources & evidence

ORD record
ord-2ac03b6f6b5b44559d7ebd85e7645f77
Source dataset
uspto-grants-2008_09
Patent number
US07429597B2

Reaction notes

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