Benzyloxyamine hydrochloride → O-Benzylhydroxylamine

O-Benzylhydroxylamine hydrochloride (1.71 g) was suspended in ethyl acetate, and the mixture was washed thoroughly with saturated aqueous sodium bicarbonate solution. the organic layer was dried (MgSO4), and evaporated under reduced pressure to leave O-benzylhydroxylamine as an oil. This was added dropwise to 3-trifluoromethylphenyl isocyanate (2.00 g), and the mixture was left to stand for 1 hour. The mixture was then dissolved in ethyl acetate and washed with 2M hydrochloric acid. The organic layer was separated, dried (MgSO4), and evaporated under reduced pressure to afford the product, yield 2.91 g.

1. washthe mixture was washed thoroughly with saturated aqueous sodium bicarbonate solution
2. dry with materialthe organic layer was dried (MgSO4)
3. customevaporated under reduced pressure

ORD record

ord-ae79c601ccf2447896dce61f8e26ea71

Source dataset

uspto-grants-1999_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05856273