反应详情

Fifteen grams of 8-amino-2,3-dihydro-4(1H) -quinolinone was dissolved in methanol (300 mL), and after addition of 3-phenylpropionaldehyde (14.6 mL) and 1N HCl (3 mL), the mixture was stirred at room temperature for 2 hrs, followed by addition of silica gel (60 g) to the reaction mixture, and the solvent was removed under reduced pressure. The residue was heated at 100° C. for 2 hrs and purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to yield the titled compound as yellow crystals (13.2 g).

1. additionfollowed by addition of silica gel (60 g) to the reaction mixture
2. customthe solvent was removed under reduced pressure
3. temperatureThe residue was heated at 100° C. for 2 hrs
4. custompurified by silica gel column chromatography (eluent: hexane/ethyl acetate)