5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine hydrochloride

HRID 341837Notes

Reaction equation

HRID 341837 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([NH2:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CO>CO>[ClH:22].[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([NH2:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 158384675,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amineHCID 21893726Hydrochloride methanol

Product 1

HCID 675980325,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine hydrochlorideYield 97.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A portion (1.9 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine obtained in Step 2 of Example 17 was dissolved in methanol (20 mL) and 10% HCl-methanol solution (3.0 g) was added slowly. The solvent was removed under reduced pressure to yield the titled compound as colorless crystals (2.1 g).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a5cb1a3c43f941a38c424e054e58c256
Source dataset
uspto-grants-1999_01
Patent number
US05856334

Reaction notes

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