反应详情

A portion (5.55 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol obtained in Example 4 was suspended in xylene (700 mL); following the addition of a Lawesson reagent (4.04 g), the suspension was heated under reflux for 30 min under an argon atmosphere. After standing to cool, the supernatant was concentrated under vacuum and the residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate) to yield the titled compound as colorless crystals (0.91 g).

1. temperaturethe suspension was heated
2. temperatureunder reflux for 30 min under an argon atmosphere
3. temperatureto cool
4. concentrationthe supernatant was concentrated under vacuum
5. customthe residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate)