Diisopropylethylamine → HCID 178463496, compound

HRID 34190Notes

Reaction equation

HRID 34190 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12](O)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:15][CH:16]([C:18]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=2[N:19]=1)[CH3:17].F[C:29]1[C:34]([O:35]C(N(C)C)=[N+](C)C)=[C:33](F)[C:32](F)=C(F)[C:30]=1F.F[P-](F)(F)(F)(F)F.C([N:57](C(C)C)CC)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:57]1[CH2:32][CH2:33][C:34](=[O:35])[CH2:29][CH2:30]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:15][CH:16]([C:18]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=2[N:19]=1)[CH3:17]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 15840204Pentafluorphenol-tetramethyluronium hexafluorophosphatHCID 1784635046-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

Product 1

HCID 178463496HCID 178463496, compound

Procedure

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 4-oxo-piperidinein DMSO at ambient temperature.

Sources & evidence

ORD record
ord-367a421a81824725ba6ad7afa67efa6a
Source dataset
uspto-grants-2008_09
Patent number
US07429597B2

Reaction notes

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