Water → HCID 17933657, compound

HRID 342031Notes

Reaction equation

HRID 342031 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([Br:17])=[C:15]([Br:18])[N:14]=[C:13]2Br)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.C([Mg]Br)C.O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([Br:17])=[C:15]([Br:18])[N:14]=[CH:13]2)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 22133000HCID 22133000, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 17933657HCID 17933657, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The operation is carried out as in Stage 2 of Example 1 starting with 6 g of the product obtained in Stage 1 of Example 1 in 300 ml of a methylene chloride/sulphuric ether mixture (60/240), to which 4.6 ml of ethyl magnesium bromide is added dropwise, then the whole is maintained under agitation for 30 minutes at ambient temperature and then 100 ml of ice-cooled water is introduced into the reaction medium obtained.

Workup

  1. additionis added dropwise
  2. additionis introduced into the reaction medium
  3. customobtained

Sources & evidence

ORD record
ord-461b754bf2cb4a41b75ae6d1bc7e0f9e
Source dataset
uspto-grants-1999_01
Patent number
US05856509

Reaction notes

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