Methanol → HCID 54278802, compound

HRID 342034Notes

Reaction equation

HRID 342034 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([CH:17]=[O:18])=[C:15]([S:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[N:14]=[C:13]2[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.[C-]#N.[Na+].[CH3:37][OH:38].C(Cl)Cl>[O-2].[Mn+2].C(O)(=O)C>[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:38][CH3:37])=[O:18])=[C:15]([S:19][C:20]3[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=3)[N:14]=[C:13]2[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1

Participants

7

Reactant 4

HCID 887MethanolHCID 6344DichloromethaneHCID 8929Sodium CyanideHCID 54108474HCID 54108474, compound

Product 1

HCID 54278802HCID 54278802, compound

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 176Acetic AcidSolvent

Procedure

The operation is carried out as in Example 9 starting with 2 g of the product of Example 20 using 10 g of manganese oxide, 1 g of sodium cyanide, 200 ml of methanol, 40 ml of methylene chloride and 600 ul of acetic acid, in this way 1.64 g of expected product is obtained (M.p.=161° C.).

Sources & evidence

ORD record
ord-3f577259a7a748b98a15d36aa6b42723
Source dataset
uspto-grants-1999_01
Patent number
US05856509

Reaction notes

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