反应详情

1-methyl-1H-indole-5-carbonitrile, a known compound, (0.4 g, 2.55 mmole) was dissolved in ethyl ether (25 mL), chilled in an ice bath and treated with oxalyl chloride (0.35 mL, 4.0 mmole, 1.6 equiv.). This mixture was stirred at room temperature overnight, then the solvent was removed by evaporation, and evaporated from CH2Cl2 again. This residue along with 2-(1-methyl-1H-indol-3yl)-acetimidic acid isopropyl ester hydrochloride (0.68 g, 2.55 mmole, 1 equiv.) was suspended in CH2Cl2 (50 mL) and cooled in an ice bath. The mixture was treated with triethylamine Et3N (1.4 mL, 10 mmole, 4 equiv.) stirred at 0° for 30 minutes, then at room temperature for an additional 3 hours. The reaction mixture was then diluted with CH2Cl2 (100 mL), washed with H2O (25 mL), and then 0.5N HCl (25 mL). The organic fractions were dried over MgSO4, filtered and evaporated to give a dark oil. The residue was taken up in toluene (50 mL), chilled in an ice bath, then treated with pTsOH (0.53 g, 2.8 mmole, 1.1 equiv.), then stirred at room temperature overnight. The toluene was evaporated, and the residue dissolved in CH2Cl2 (100 mL), then washed with saturated NaHCO3 (30 mL), H2O (30 mL), and brine (30 mL). The organic layer was dried over MgSO4, filtered and evaporated, then purified by flash column chromatography (10% ethyl acetate (EtOAc)/Hexane). The product was further purified by washing with cold CH2Cl2 to provide 0.43 g of 1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3yl]-1H-indole-5-carbonitrile.

1. temperaturechilled in an ice bath
2. customthe solvent was removed by evaporation
3. customevaporated from CH2Cl2 again
4. temperaturecooled in an ice bath
5. stirringstirred at 0° for 30 minutes
6. waitat room temperature for an additional 3 hours
7. washwashed with H2O (25 mL)
8. dry with materialThe organic fractions were dried over MgSO4
9. filtrationfiltered
10. customevaporated
11. customto give a dark oil
12. temperaturechilled in an ice bath
13. stirringstirred at room temperature overnight
14. customThe toluene was evaporated
15. dissolutionthe residue dissolved in CH2Cl2 (100 mL)
16. washwashed with saturated NaHCO3 (30 mL), H2O (30 mL), and brine (30 mL)
17. dry with materialThe organic layer was dried over MgSO4
18. filtrationfiltered
19. customevaporated
20. custompurified by flash column chromatography (10% ethyl acetate (EtOAc)/Hexane)
21. customThe product was further purified
22. washby washing with cold CH2Cl2