反应详情

A solution of methyl benzofuran-7-carboxylate (5.34 g, 30 mmol) was added to a suspension of LAH (2.31 g, 61 mmol) in THF and then heated to reflux for 30 min. The reaction was quenched with ethyl acetate and water. The mixture was made acidic with 12N HCl until all the precipitate dissolved. The ethyl acetate layer was separated, washed with water, dried with brine, and concentrated in vacuo to give a yellow oil (4.03 g, 91%).

1. temperatureheated
2. temperatureto reflux for 30 min
3. customThe reaction was quenched with ethyl acetate and water
4. dissolutiondissolved
5. customThe ethyl acetate layer was separated
6. washwashed with water
7. dry with materialdried with brine
8. concentrationconcentrated in vacuo