Methyl 2,3-dihydrobenzofuran-7-carboxylate → (2,3-Dihydro-1-benzofuran-7-yl)methanol

HRID 342088Notes

Reaction equation

HRID 342088 reaction equation
[O:1]1[C:5]2[C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[O:1]1[C:5]2[C:6]([CH2:10][OH:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 15062252Methyl 2,3-dihydrobenzofuran-7-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 2795020(2,3-Dihydro-1-benzofuran-7-yl)methanolYield 80%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 2,3-dihydro-benzofuran-7-carboxylate (12 g, 68 mmol) was reduced with LAH (5.14 g, 136 mmol) in THF similar to the above procedures to give the product as a dark oil (8.13 g, 80%).

Sources & evidence

ORD record
ord-a09967d412c94083880e512673ba0b20
Source dataset
uspto-grants-1999_01
Patent number
US05856529

Reaction notes

Loading…