反应详情

温度

55 °C

2-[1-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid methyl ester (0.92 g, 3.28 mmol ) was dissolved in 2.5N hydrochloric acid (50 ml) and heated to 55° C. for 3 h. After this time, the solution was concentrated to dryness in vacuo to give the title compound as a white solid. 1HNMR (CD3OD, 400 MHz) δ 8.92(1H, s),7.94(1H, d, J=8.6 Hz), 7.88(2H, m), 7.93(1H, s), 7.54(3H, m), 7.43(1H, d, J=14 Hz), 5.60(2H, s) and 3.82(2H, s) ppm.

1. concentrationAfter this time, the solution was concentrated to dryness in vacuo