反应详情

A solution of 4-(tert-butyldimethylsilyloxymethyl)-1-triphenylmethylimidazole (4.66 g, 10.26 mmol) and 1-bromomethyl-4-cyanobenzene (2.01 g, 10.26 mmol) in acetonitrile (50 mL) was refluxed 4 h. The reaction was cooled, acetonitrile removed in vacuo, and the residue dissolved in methanol (30 mL). This solution was refluxed for 2 h, cooled and methanol evaporated. The residue was partitioned between ethyl acetate and saturated sodium bicarbonate. The crude product was chromatographed on silica with 3% methanol in chloroform. The title compound was obtained as a white solid.

1. temperatureThe reaction was cooled
2. customacetonitrile removed in vacuo
3. dissolutionthe residue dissolved in methanol (30 mL)
4. temperatureThis solution was refluxed for 2 h
5. temperaturecooled
6. custommethanol evaporated
7. customThe residue was partitioned between ethyl acetate and saturated sodium bicarbonate
8. customThe crude product was chromatographed on silica with 3% methanol in chloroform