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HRID342163

反应详情

EQUATION

反应方程式

HRID 342163 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
HCID36314

Paclitaxel

C47H51NO14

结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]21)C3(C)C
HCID46783796

未命名化合物

PRODUCTS

生成物

3
结构：C/C=C(\C)C(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@]3(C)C(=O)[C@H](O)C(=C1C)C2(C)C
HCID15222311

10-Deacetyl-7-xylosyltaxol B

C48H59NO17

结构：CCCCCC(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@]3(C)C(=O)[C@H](O)C(=C1C)C2(C)C
HCID15222314

7-Xylosyl-10-deacetyltaxol C

C49H63NO17

结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]21)C3(C)C
HCID46783796

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

According to the first objective of the present invention, an improved process has been developed for isolation of the taxol analogues 7-xylosyl-10-deacetyl taxol A, B, C from the stem bark of Taxus wallichiana in which no solvent partitioning has been used to isolate the analogues. The improved isolation process comprises extracting air dried, pulverized plant materials with alcohols at room temperature, evaporating the solvent to obtain a residue, stirring the resultant residue with water to obtain a thick precipitate, isolating the analogues 7-xylosyl-10-deacetyl-taxol A, 7-xylosyl-10-deacetyl-taxol B and 7-xylosyl-10-deacetyl taxol C from the precipitate by flash chromatography over a bed of silica gel.

WORKUP

后处理

  1. custompartitioning
  2. customto isolate the analogues
  3. extractionThe improved isolation process comprises extracting air
  4. customdried
  5. customat room temperature
  6. customevaporating the solvent
  7. customto obtain a residue
  8. customto obtain a thick precipitate