HRID342196

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12368

1,6-Dibromohexane

C6H12Br2

HCID69391

2-Propen-1-amine, N-methyl-

C4H9N

HCID15422641

3-(4-Bromophenyl)-6-methoxy-1-benzothiophene

C15H11BrOS

PRODUCTS

生成物

结构：C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)csc2c1

HCID10917490

未命名化合物

结构：BrCCCCCCOc1ccc2c(-c3ccc(Br)cc3)csc2c1

HCID10972696

未命名化合物

HCID17932888

未命名化合物

PROCEDURE

实验过程

From 3-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene, after cleavage of the methoxy protecting group (analogously to Ex. Ab), reaction with 1,6-dibromohexane (analogously to Ex. Ac) and N-allyl-methyl-amine and salt formation (analogously to Ex. Ad), via 3-(4-bromo-phenyl)-benzo[b]thiophen-6-ol and via 6-(6-bromo-hexyloxy)-3-(4-bromo-phenyl)-benzo[b]thiophene there is obtained allyl-[6-[3-(4-bromo-phenyl)-benzo[b]thiophen-6-yloxy]-hexyl]methyl-amine.fumarate (1:1), MS: m/e 457 (M+H30 , Br).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-60c0ad31f3934f50b2d4eb122f530373
来源数据集: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05856503
来源说明: uspto-grants-1999_01

反应 SMILES

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]Br.[CH2:27]([NH:30][CH3:31])[CH:28]=[CH2:29]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=3)=[CH:12][S:11][C:10]=2[CH:13]=1.[CH2:27]([N:30]([CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=3)=[CH:12][S:11][C:10]=2[CH:13]=1)[CH3:31])[CH:28]=[CH2:29]