HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1-(4-Bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 1-(4-Bromo-phenyl)-6-methoxy-3,4-dihydro-isoquinoline | HCID 11823227 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(4-Bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol | HCID 135980795 | 95.6% |
Reaction Steps
Cleavage of the methoxy protecting group (analogously to Ex. 14c) from 1-(4-bromo-phenyl)-6-methoxy-3,4-dihydro-isoquinoline (15 g) is effected with 95 ml of acetic acid and 65 ml of 62% aqueous hydrobromide solution at 100° C. and gives 13.7 g of 1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol, MS: m/e 301 (M+, 1 Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856503 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-ac9ed99a7ec249568ce12d15d37cefee |
| Source note | uspto-grants-1999_01 |