反应详情

Cleavage of the methoxy protecting group (analogously to Ex. 14c) from 1-(4-bromo-phenyl)-6-methoxy-3,4-dihydro-isoquinoline (15 g) is effected with 95 ml of acetic acid and 65 ml of 62% aqueous hydrobromide solution at 100° C. and gives 13.7 g of 1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol, MS: m/e 301 (M+, 1 Br).