反应详情

温度

50 °C

5.6 g of 2,3-dicyanohydroquinone and 4.6 g of 85%-potassium hydroxide were added to a mixture solvent to 15 ml of methanol and 60 ml of N,N-dimethylformamide, followed by heating to 50° C. to provide a solution. To the solution, 11.0 g of 4-n-pentylcyclohexylmethyl methanesulfonate was added, followed by stirring for 3 hours at 100° C. After the reaction, the reaction mixture was poured into cold water and washed with ether. The water layer was acidified with 6N-hydrochloric acid aqueous solution until a pH value of 1 was shown, and was subjected to extraction with ether. The organic layer was washed successively with 5%-sodium hydrogenecarbonate aqueous solution and water, followed by drying with anhydrous magnesium sulfate and distilling-off of the solvent to obtain a crude product. The crude product was purified by silica gel column chromatography (eluent: toluene-ethyl acetate) and treated with activated carbon, followed by recrystallization from methanol to obtain 3.6 g of 4-n-pentylcyclohexylmethyl 2,3-dicyano-4-hydroxyphenyl ether.

1. customto provide a solution
2. customAfter the reaction
3. washwashed with ether
4. extractionwas subjected to extraction with ether
5. washThe organic layer was washed successively with 5%-sodium hydrogenecarbonate aqueous solution and water
6. dry with materialby drying with anhydrous magnesium sulfate and distilling-off of the solvent
7. customto obtain a crude product
8. customThe crude product was purified by silica gel column chromatography (eluent: toluene-ethyl acetate)
9. additiontreated with activated carbon
10. customfollowed by recrystallization from methanol