Hydrochloric Acid → HCID 70199009, compound

HRID 342417Notes

Reaction equation

HRID 342417 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][C:9]1[O:13][C:12]2[C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=[CH:17][C:11]=2[CH:10]=1)=[O:5])C.[OH-].[Na+].C(O)C.Cl>O>[C:4]([CH2:6][CH2:7][CH2:8][C:9]1[O:13][C:12]2[C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=[CH:17][C:11]=2[CH:10]=1)([OH:5])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 70197073HCID 70197073, compound

Product 1

HCID 70199009HCID 70199009, compoundYield 83.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 2-(3-ethoxycarbonylpropyl)-7-nitrobenzo[b]furan (1.0 g) in a mixture of aqueous 1N-sodium hydroxide (7.2 ml) and ethanol (5 ml) was stirred at 50° C. for 1 hour. The reaction mixture was diluted with water and acidified with 4N-hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(3-carboxypropyl)-7-nitrobenzo[b]furan (752 mg).

Workup

  1. customThe separated solid was collected
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-886ad07cdd2340afb00e544d0edc2652
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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