Thiourea → HCID 86753554, compound

HRID 342425Notes

Reaction equation

HRID 342425 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[C:6]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:7]=2[O:8][C:9]=1[CH3:10])=O.[NH2:18][C:19]([NH2:21])=[S:20]>C(O)C>[ClH:1].[NH2:21][C:19]1[S:20][CH:2]=[C:3]([C:5]2[C:6]3[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:7]=3[O:8][C:9]=2[CH3:10])[N:18]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 86753556HCID 86753556, compound

Product 1

HCID 86753554HCID 86753554, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-chloroacetyl-2-methyl-7-nitrobenzo[b]furan (431 mg) and thiourea (194 mg) in ethanol (10 ml) was refluxed for 1.5 hours. The separated solid was collected, washed with ethanol and dried to give 3-(2-aminothiazol-4-yl)-2-methyl-7-nitrobenzo[b]furan hydrochloride (485 mg).

Workup

  1. temperaturewas refluxed for 1.5 hours
  2. customThe separated solid was collected
  3. washwashed with ethanol
  4. customdried

Sources & evidence

ORD record
ord-0fdc73e4992444149414c304b86cbdc8
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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