2-Ethyl-3-methyl-7-nitrobenzo[b]furan → (2-Ethyl-3-methyl-1-benzofuran-7-yl)amine

HRID 342443ノート

反応式

HRID 342443 の反応式
[CH2:1]([C:3]1[O:7][C:6]2[C:8]([N+:12]([O-])=O)=[CH:9][CH:10]=[CH:11][C:5]=2[C:4]=1[CH3:15])[CH3:2]>CO.O1CCOCC1.[C].[Pd]>[NH2:12][C:8]1[C:6]2[O:7][C:3]([CH2:1][CH3:2])=[C:4]([CH3:15])[C:5]=2[CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 1

HCID 702012322-Ethyl-3-methyl-7-nitrobenzo[b]furan

生成物 1

HCID 25219482(2-Ethyl-3-methyl-1-benzofuran-7-yl)amine収率 100.5%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 2-ethyl-3-methyl-7-nitrobenzo[b]furan (1.00 g) in a mixture of methanol (15 ml) and dioxane (10 ml) was added 10% palladium carbon (100 mg) and the above mixture was hydrogenated at 3 atom for 1 hour. The catalyst was filtered off and the filtrate was evaporated in vacuo to give 7-amino-2-ethyl-3-methylbenzo[b]furan (858 mg) as an oil.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-1ac95174c9a348449c08125b550a52ed
出典データセット
uspto-grants-1999_01
特許番号
US05858995

反応ノート

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