1-(2-Chlorophenyl)-2-piperazinone → HCID 54004906, compound

HRID 342494Notes

Reaction equation

HRID 342494 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N+:5]([O-])=[CH:4][C:3]=1[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][C:26]1=[O:31]>>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][C:3]2[CH:4]=[N:5][CH:6]=[CH:7][C:2]=2[N:28]2[CH2:29][CH2:30][N:25]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[Cl:18])[C:26](=[O:31])[CH2:27]2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 154000161-(2-Chlorophenyl)-2-piperazinoneHCID 53849539HCID 53849539, compound

Product 1

HCID 54004906HCID 54004906, compound

Procedure

The product of step B is heated with 1-(2-chlorophenyl)-piperazin-2-one (1 molar equivalent). The crude N-oxide of 4-[3-(4-methoxybenzyl)pyrid -4-yl]-I-(2-chlorophenyl)-piperazin-2-one is deoxygenated by treatment with triphenylphosphine (2 molar equivalents) to provide the title compound.

Workup

  1. customThe crude N-oxide of 4-[3-(4-methoxybenzyl)pyrid -4-yl]-I-(2-chlorophenyl)-piperazin-2-one is deoxygenated by treatment with triphenylphosphine (2 molar equivalents)

Sources & evidence

ORD record
ord-0b4e27cadee940f98cdaf1acf8608f73
Source dataset
uspto-grants-1999_01
Patent number
US05859015

Reaction notes

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