反应详情

A mixture of 1-cyanocycloprop-1-ylmethanol (4.31 g, 44.4 mmol), obtained as in the proceeding paragraph, triethylamine (9.04 mL, 64.8 mmol) and methylene chloride (78 mL) was cooled under argon to between 0° and 5° C. and methanesulfonyl chloride (4.67 mL, 59.9 mmol) was added slowly. The mixture was cooled 3 hours with stirring at 0° to 5° C., then diluted with water and extracted with methylene chloride. The extract was washed with 5% sodium bicarbonate, dried (MgSO4) and concentrated to dryness to give 1-cyano-cycloprop-1-ylmethyl methanesulfonate.

1. temperaturewas cooled under argon to between 0° and 5° C.
2. temperatureThe mixture was cooled 3 hours
3. extractionextracted with methylene chloride
4. washThe extract was washed with 5% sodium bicarbonate
5. dry with materialdried (MgSO4)
6. concentrationconcentrated to dryness