1-(4-Chloro-2-methoxyphenyl)piperazine → 3-benzyl-1-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342568Notes

Reaction equation

HRID 342568 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[CH2:16]([N:23]1[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH2:31][CH2:32][CH2:33]Cl)[C:24]1=[O:35])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[ClH:1].[CH2:16]([N:23]1[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH2:31][CH2:32][CH2:33][N:11]2[CH2:10][CH2:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=3[O:14][CH3:15])[CH2:13][CH2:12]2)[C:24]1=[O:35])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 158406631-(4-Chloro-2-methoxyphenyl)piperazineHCID 158406671-(3-chloropropyl)-3-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 702012693-benzyl-1-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-(4-chloro-2-methoxyphenyl)piperazine and 3-benzyl-1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 3-benzyl-1-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 194°-195° C.; Anal.: Calcd. for C26H31ClN4O3.(HCl)2 : C, 55.63; H, 6.03; N, 9.98%; Found: C, 55.82; H, 5.94; N, 9.85%;

Sources & evidence

ORD record
ord-58dcc80374804b8fac3787586d77a41d
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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