1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → 1-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342571Notes

Reaction equation

HRID 342571 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:19]([N:26]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[C:29](=[O:36])[N:28]([CH2:37][CH2:38][CH2:39][Cl:40])[C:27]1=[O:41])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[ClH:40].[CH2:19]([N:26]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[C:29](=[O:36])[N:28]([CH2:37][CH2:38][CH2:39][N:14]2[CH2:15][CH2:16][N:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][CH2:3][C:2]([F:1])([F:17])[F:18])[CH2:12][CH2:13]2)[C:27]1=[O:41])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 54525005HCID 54525005, compound

Product 1

HCID 867535651-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-benzyl-3-(3-chloropropyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 125°-127° C.; Anal.: Calcd. for C27H28F6N4O3.HCl: C, 52.65; H, 4.91; N, 9.10%; Found: C, 52.44; H, 4.79; N, 8.92%;

Sources & evidence

ORD record
ord-92958344eb684715a191c7bb8cf415c8
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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