HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → 1-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine | HCID 10491565 | — |
| Reactant | HCID 54525005 | HCID 54525005 | — |
| Product | 1-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 86753565 | — |
Reaction Steps
substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-benzyl-3-(3-chloropropyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-(4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl)propyl)-5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 125°-127° C.; Anal.: Calcd. for C27H28F6N4O3.HCl: C, 52.65; H, 4.91; N, 9.10%; Found: C, 52.44; H, 4.79; N, 8.92%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-92958344eb684715a191c7bb8cf415c8 |
| Source note | uspto-grants-1999_01 |